王永刚

发布时间：2024-06-11 09:04:00 阅读量：

【字体：大中小】

【基本情况】

王永刚，主任医师，首都医科大学附属北京天坛医院头痛科主任，专业型博士研究生导师、专业型硕士研究生导师。Journal of Headache and Pain杂志副主编

【学习经历】

1994.09-1999.06 河南医科大学医学学士

2001.09-2004.06 郑州大学医学院神经解剖学硕士

2004.09-2007.07 中国人民解放军第二军医大学神经生物学博士

【工作经历】

1999.07-2006.10 郑州大学医学院人体解剖学教研室助教

2007.07-2013.02 上海市第十人民医院神经内科

2007.07-2009.12 住院医师/主治医师/讲师

2010.01-2011.09 副主任医师/硕士生导师

2013.03-2019.08 上海交通大学医学院附属仁济医院神经内科

2013.03-2016.12 副主任医师/硕士生导师

2017.01-2017.06 主任医师/硕士生导师

2017.07-2019.08 主任医师/博士生导师

2019.09-至今首都医科大学附属北京天坛医院头痛科主任主任医师/教授/博士生导师

【目前承担课程】

首都医科大学《临床神经生物学》课程

【主要科研成果】

研究方向：

1. 原发性头痛的临床、影像与基础研究

2. 神经损伤修复，脑网络，脑功能与神经环路研究

3. 脑小血管病与头痛相关疾病的临床和基础研究

主持或参与科研项目：

1.项目编号：32170752，国家自然科学基金委面上项目资助，《内皮细胞自噬参与斑马鱼发育期脑血管修剪的机制研究》58万元批准年度：2022.01-2025.12

2.项目编号：Z200024，北京市自然科学基金委重点研究专题，《基于像电磁一体化的多模态脑网络研究在颞叶癫痫精准诊断中的应用》75万元 2020.09-2024.09

3.项目编号：2-1-1-951-03，北京市科委，《王永刚-原发性头痛的遗传学和临床影像学研究-2-1-1-951-03》20万元 2020.01-2022.12

4.项目编号：91849104，国家自然科学基金委重大研究计划培育项目，《RBM8a介导Wnt信号调节神经元再生在衰老过程中的作用及机制研究》50万元 2019.01-2021.12

5.项目编号：31770800，国家自然科学基金委面上项目资助，《内源性硫化氢影响斑马鱼脑血管发育的机制研究》55万元 2018.01-2021.12

6.项目编号：20161414，上海市教委——高峰临床医学“研究型医师”,《重症肌无力及相关神经免疫疾病抗体检测技术临床应用与推广》100万元，2016.07-2019.06

7.项目编号：81571329，国家自然科学基金委面上项目资助，《汉族人群重症抑郁症候选基因筛查、分子网络分析及其功能验证》68.4万元 2016.01-2019.12

8.项目编号：31240001，国家自然科学基金委专项基金资助，《Trpc3/6介导Neuregulin-1引起的钙内流参与外周雪旺细胞髓鞘化》 15万元， 2012.06—2013.05

9.项目编号：31271140，国家自然科学基金委面上项目资助，《神经干细胞巢内小胶质细胞对Wnt/β-catenin通路的调节机制及其在多发性硬化发病中的机制研究》 80万元， 2013.01—2016.12；

10.项目编号：2008KJ063 同济大学青年优秀人才培养行动计划资助《生存素参与依达拉奉抗凋亡的机制研究》1.5万元 2009.01—2010.12

11.项目编号：2009QN006 上海市第十人民医院优秀青年人才培养计划资助 6万元 2009.07.01—2012.6.30

发表主要论文或专著

1. Bai, X., Wang, W., Zhang, X., Hu, Z., Zhang, X., Zhang, Y., Tang, H., Zhang, Y., Yu, X., Yuan, Z., Zhang, P., Li, Z., Pei, X., Wang, Y., & Sui, B. (2023). Hyperperfusion of bilateral amygdala in patients with chronic migraine: an arterial spin-labeled magnetic resonance imaging study. The journal of headache and pain, 24(1), 138. https://doi.org/10.1186/s10194-023-01668-0

2. Zhang, X., Wang, W., Bai, X., Zhang, X., Yuan, Z., Jiao, B., Zhang, Y., Li, Z., Zhang, P., Tang, H., Zhang, Y., Yu, X., Bai, R., Wang, Y., & Sui, B. (2023). Increased glymphatic system activity in migraine chronification by diffusion tensor image analysis along the perivascular space. The journal of headache and pain, 24(1), 147. https://doi.org/10.1186/s10194-023-01673-3

3. Qiu, D., Ge, Z., Mei, Y., Wang, W., Xiong, Z., Li, X., Yuan, Z., Zhang, P., Zhang, M., Liu, X., Zhang, Y., Yu, X., Tang, H., & Wang, Y. (2023). Mapping brain functional networks topological characteristics in new daily persistent headache: a magnetoencephalography study. The journal of headache and pain, 24(1), 161. https://doi.org/10.1186/s10194-023-01695-x

4. Mei, Y., Wang, W., Qiu, D., Yuan, Z., Bai, X., Tang, H., Zhang, P., Zhang, X., Zhang, Y., Yu, X., Sui, B., & Wang, Y. (2023). Micro-structural white matter abnormalities in new daily persistent headache: a DTI study using TBSS analysis. The journal of headache and pain, 24(1), 80. https://doi.org/10.1186/s10194-023-01620-2

5. Yuan, Z., Li, W., Tang, H., Mei, Y., Qiu, D., Zhang, M., Sun, Q., Wang, W., Zhang, P., Ma, Z., Zhang, X., Zhang, Y., Wang, Y., & Yu, X. (2023). Enlarged perivascular spaces in patients with migraine: a case-control study based on 3T MRI. Annals of clinical and translational neurology, 10.1002/acn3.51798. Advance online publication. https://doi.org/10.1002/acn3.51798

6. Zhang, X., Wang, W., Zhang, X., Bai, X., Yuan, Z., Zhang, P., Bai, R., Jiao, B., Zhang, Y., Li, Z., Tang, H., Zhang, Y., Yu, X., Wang, Y., & Sui, B. (2023). Normal glymphatic system function in patients with new daily persistent headache using diffusion tensor image analysis along the perivascular space. Headache, 63(5), 663–671. https://doi.org/10.1111/head.14514

7. Qiu, D., Wang, W., Mei, Y., Tang, H., Yuan, Z., Zhang, P., Zhang, Y., Yu, X., Yang, C., Wang, Q., & Wang, Y. (2023). Brain structure and cortical activity changes of new daily persistent headache: multimodal evidence from MEG/sMRI. The journal of headache and pain, 24(1), 45. https://doi.org/10.1186/s10194-023-01581-6

8. Wang, W., Yuan, Z., Zhang, X., Bai, X., Tang, H., Mei, Y., Qiu, D., Zhang, Y., Zhang, P., Zhang, X., Zhang, Y., Yu, X., Sui, B., & Wang, Y. (2023). Mapping the aberrant brain functional connectivity in new daily persistent headache: a resting-state functional magnetic resonance imaging study. The journal of headache and pain, 24(1), 46. https://doi.org/10.1186/s10194-023-01577-2

9. Zhang, X., Wang, W., Bai, X., Mei, Y., Tang, H., Yuan, Z., Zhang, X., Li, Z., Zhang, P., Hu, Z., Zhang, Y., Yu, X., Sui, B., & Wang, Y. (2023). Alterations in regional homogeneity and multiple frequency amplitudes of low-frequency fluctuation in patients with new daily persistent headache: a resting-state functional magnetic resonance imaging study. The journal of headache and pain, 24(1), 14. https://doi.org/10.1186/s10194-023-01543-y

10. Xiaoyan Bai, Wei Wang, Xueyan Zhang#, Zhangxuan Hu, Yingkui Zhang, Zhiye Li, Xue Zhang, Ziyu Yuan, Hefei Tang, Yaqing Zhang, Xueying Yu, Peng Zhang, Yonggang Wang, Binbin Sui. Cerebral perfusion variance in new daily persistent headache and chronic migraine: an arterial spin-labeled MR imaging study, Journal of Headache and Pain.

11. Xueyan Zhang, Wei Wang, Xiaoyan Bai#, Yingkui Zhang, Ziyu Yuan, Hefei Tang, Xue Zhang, Zhiye Li, Peng Zhang, Zhangxuan Hu, Yaqing Zhang, Xueying Yu, Xue Man, Binbin Sui, Yonggang Wang. Changes in gamma-aminobutyric acid and glutamate/glutamine levels in the right thalamus of patients with episodic and chronic migraine: A proton magnetic resonance spectroscopy study, Headache.2022;

12. Ziyu Yuan, Wei Wang, Xueyan Zhang, Xiaoyan Bai, Hefei Tang, Yanliang Mei, Peng Zhang, Dong Qiu, Xue Zhang, Yaqing Zhang, Xueying Yu, Binbin Sui and Yonggang Wang. Altered functional connectivity of the right caudate nucleus in chronic migraine: a resting-state fMRI study, Journal of Headache and Pain. 2022; 15;23(1):83

13. Wei Wang, Xueyan Zhang, Xiaoyan Bai, Yingkui Zhang, Ziyu Yuan, Hefei Tang, Zhiye Li, Zhangxuan Hu, Yaqing Zhang, Xueying Yu, Binbin Sui and Yonggang Wang. Gamma-aminobutyric Acid and Glutamate/Glutamine Levels in the Dentate Nucleus and Periaqueductal Gray With Episodic and Chronic Migraine: A Proton Magnetic Resonance Spectroscopy Study, Journal of Headache and Pain. 2022; 15;23(1):83.

14. Shouyi Wu, Xiao Ren, Chenlu Zhu, Wei Wang, Kaibo Zhang, Zhilei Li, Xuejiao Liu, Yonggang Wang. A c-Fos activation map in nitroglycerin/ levcromakalim-induced models of migraine, Journal of Headache and Pain. 2022; 23, 128 (2022).

15. Ren X, Yao LL, Pan JX, Zhang JS, Mei L, Wang YG, Xiong WC. Linking cortical astrocytic neogenin deficiency to the development of Moyamoya disease-like vasculopathy. Neurobiol Dis. 2021;154:105339.

【社会兼职和社会服务】

中华医学会神经病学分会头痛协作组组长

中国卒中学会头痛分会主任委员

北京神经内科学会头痛分会主任委员

【联系方式】

E-mail：w100yg@163.com