陈　巧

职务/职称：副教授/硕导

研 究 所：药物化学研究所

电子邮件：chenqiao@lzu.edu.cn

【基本情况】

2011-2016年于兰州大学获得理学博士学位；2016年10月至2019年9月在新加坡南洋理工大学从事博士后研究。2019年9月至今在兰州大学药学院工作。

【研究方向】具有药物活性的小分子的设计与合成，药物分子的结构修饰及生物活性研究。

【主讲课程】《有机化学实验》

【研究成果】

发明专利一项：

1. 许兆青，陈巧，于红梅，王国强，一种芳炔的合成方法. 专利号: ZL   201410489226.2 (2017-01-18).

共参与发表SCI论文十余篇：

[1] Q. Chen, T. Zhu, P. K. Majhi, C. Mou, H. Chai, J. Zhang, S. Zhuo, Y. R. Chi, Carbene-catalyzed enantioselective oxidative coupling of enals and di(hetero)arylmethanes, Chem. Sci. 2018, 9, 8711-8715. (SCI一区, IF 9.063) 

[2] Q. Chen, J. Zhou, Y. Wang, C. Wang, X. Liu, Z. Xu, L. Lin, R. Wang, Transition-Metal-Free Dehydrosilylative   Difluoroamidation of Tetrahydroisoquinolines under Mild Conditions, Org. Lett. 2015, 17, 4212–4215. (SCI一区, IF 6.492)

[3] Q. Chen, G. Wang, X. Jiang, Z. Xu, L. Lin, R. Wang, Highly Enantioselective Organocatalyzed Vinylogous Michael-Type   Reaction for the Construction of Trifluoromethylated All-Carbon Quaternary   Stereocenters, Org. Lett. 2014,   16, 1394–1397. (SCI一区, IF 6.492)

[4] Q. Chen, J. Liang, S. Wang, D. Wang, R. Wang, An asymmetric approach toward chiral multicyclic spirooxindoles from   isothiocyanato oxindoles and unsaturated pyrazolones by a chiral tertiary   amine thiourea catalyst, Chem. Commun. 2013, 49, 1657–1659.   (SCI一区, IF 6.29)

[5] Q. Chen,   Y. Lei, Y. Wang, C. Wang, Y. Wang, Z. Xu, H. Wang, R. Wang, Direct   thiocyanation of ketene dithioacetals under transition-metal-free conditions, Org. Chem. Front. 2017, 4,   369–372. (SCI二区, IF 5.455)

[6] Q. Chen, C. Wang, J. Zhou,   Y. Wang, Z. Xu, R. Wang, CuSO4-Mediated   Decarboxylative Difluoroacetamidation of α,β-Unsaturated Carboxylic Acids, J. Org. Chem. 2016, 81, 2639–2645. (SCI二区, IF 4.805)

[7] Q. Chen, H. Yu, Z. Xu, L.   Lin, X. Jiang, R. Wang, Development and   Application of O-(Trimethylsilyl)aryl Fluorosulfates for the Synthesis of Arynes, J. Org. Chem. 2015, 80, 6890–6896. ( SCI二区, IF 4.805)

[8] C. Wang+, Q. Chen+, Q. Guo, H. Liu, Z. Xu, Y. Liu, M. Wang, R. Wang, Silver-Catalyzed Difluoroamidation of Activated Alkenes for the   Construction of Difluorinated 3,3-Disubstituted Oxindoles, J. Org. Chem. 2016, 81,   5782–5788. (并列第1作者, SCI二区, IF   4.805)

[9] Y. Liu, Q. Chen, C. Mou, L. Pan, X.   Duan, X. Chen, H. Chen, Y. Zhao, Y. Lu, Z. Jin, Y. R. Chi, Catalytic asymmetric acetalization of   carboxylic acids for access to chiral phthalidyl ester prodrugs. (Nat.   Commun. https://doi.org/10.1038/s41467-019-09445-x, SCI一区, IF 12.353)

[10] J. Liang, Q. Chen, L. Liu,   X. Jiang, R. Wang, An organocatalytic asymmetric double Michael cascade reaction of unsaturated ketones and   unsaturated pyrazolones: highly efficient synthesis of spiropyrazolone derivatives, Org. Biomol. Chem. 2013, 11, 1441–1445.

[11] X. Liu, Q. Chen, W. Li, Y.   Liang, R. Wang, Synthesis of   3-Aroyl-4-hydroxy-4-arylpiperidine Derivatives by DBU-Catalyzed Reactions of   Amines with Vinyl Ketones, Synlett 2012, 23, 1691–1695.

[12] Y. Zhu, X. Li, Q. Chen, J. Su, F. Jia, S. Qiu, M. Ma, Q. Sun, W. Yan, K. Wang, R. Wang, Highly Enantioselective Cascade Reaction   Catalyzed by Squaramides: the Synthesis of CF3-Containing Chromanes, Org. Lett. 2015, 17, 3826–3829. (SCI一区, IF 6.492)

[13] X. Liu, H. Song, Q. Chen, W. Li, W. Yin, M. Kai, R. Wang, An Asymmetric Organocatalytic Approach to   Michael Reactions of Thiazolones and Nitroalkenes: Preparation of Compounds   with Anti-Cancer Potency, Eur. J. Org.   Chem. 2012,   2012, 6647–6655.

[14] L. Zhu, H. Yu, Q. Guo, Q. Chen, Z. Xu, R. Wang, C–H Bonds Phosphorylation of Ketene Dithioacetals, Org. Lett. 2015, 17, 1978–1981. (SCI一区, IF 6.492)    

[15] W. Li, X. Liu, Z. Mao, Q. Chen, R. Wang, New approach to the preparation of bicycle octane derivatives via the enantioselective cascade reaction catalyzed by chiral diamine-Ni(OAc)2 complex, Org. Biomol. Chem. 2012, 10, 4767–4773.