姓 名：陈根

Name：Chen Gen

职 务：副教授

Duty: Associate Professor

E-mail：chengen@lzu.edu.cn

一、科研方向

1. 模式生物秀丽隐杆线虫作为感染模型的研究；

2. 黑热病,包虫病和幽门螺杆菌感染的分子流行病学及防治研究；

3. 线虫作为环境指示生物的研究；

4. 抗菌材料和药物的研究。

1. Research of Model organism Caenorhabditis elegans as infective model.

2. Research of molecule epidemiology and control of Kala-azar, echinococcosis, and Helicobacter pylori infection.

3. Study on direct nematode as biological indicator.

4. Study on Antibacterial material and drug.

二、荣誉称号及奖励

获2008年度甘肃省科技进步三等奖。

honors and awards：

Won the third grade Award of the Technology Advancement of Gansu Province in 2008。

三、个人简历

陈根，男，陕西省汉阴人。博士，兰州大学病原生物学研究所，副教授，硕士生导师。1998年7月于兰州医学院预防医学专业本科毕业；2002年6月获得兰州医学院病原生物学专业硕士学位，同年留校；从事医学各专业《人体寄生虫学》和《医学微生物学》的理论和实验教学工作。2009年6月获得兰州大学动物学专业博士学位。目前主要从事有关模式生物秀丽隐杆线虫（Caenorhabditis elegans，C. elegans）、黑热病、肠道线虫感染、包虫病和幽门螺杆菌等分子生物学、致病机制、遗传学和流行病学的研究工作。

2001-2005年参与NIH合作项目《parasitc zoonosis transmission in China》，承担包虫病的流行与防治研究。

2008年参与自然科学基金项目《黄河灌溉区湿地污水处理系统的建立及农业生态恢复研究》（No. 30770390），主要对土壤生物线虫多样性进行调查研究。2008年参与甘肃省自然科学基金项目《河西走廊的高镍环境对幽门螺杆菌致病性及尿素酶遗传特性的影响》（No. 0803RJZA073），承担幽门螺杆菌的实验研究。

2010年主持中央高校基本科研业务费自由探索项目-面上项目《肠道杆菌影响秀丽隐杆线虫线虫衰老机制的研究》（No.lzujbky-2010-124），承担以秀丽隐杆线虫作为模式生物研究衰老的机制。

2010年参与甘肃省自然科学基金项目《阿苯达唑亚砜及其对映体抗包虫作用及毒性研究》（No.1010RJZA103），承担包虫动物实验的研究。

2011年主持国家自然科学基金《以秀丽隐杆线虫作为寄生虫耐药模型的研究（No.31172174），负责课题设计、实施和完成。

2011年参与两项国家自然科学基金面上项目：《基于可视化复频宽焦超声诱导及靶向控制给药的肝包虫治疗新方法及作用机制研究》（No.81171632），承担靶向控制给药的研究，《黄河上游农业生态系统中复合污染物的环境过程及生态效应》（No.41171391），承担线虫作为指示生物的研究。

2011年主持教育部春晖计划《黑热病在甘肃省陇南地区传播风险评估的研究》（No.Z2010083），负责课题设计、实施和完成。

先后发表论文20余篇，参编教材1部。

Chen Gen, male, Phd，born from Hanyin County, Shaanxi Province, is associate professor and master tutor of Institute of Pathogenic Biology in Lanzhou University. Chen Gen majored Preventive medicine and graduated from Lanzhou Medical College in 1998 June. He majored Pathogenic Biology and received master's degree form Lanzhou Medical College in 2002 June, and stayed Pathogenic Biology Research Institute as a teacher in the same year the school. He has teached two courses (including human parasitology and medical microbiology) for all medical specialties students. He majored Zoology in Lanzhou University and received Phd. In 2009 June. At present, he mainly engaged in molecular biology, pathogenesis, genetics and epidemiology research disease of the model organism Caenorhabditis elegans, kala-azar, intestinal nematode infection, hydatid and Helicobacter pylori et al.

In 2001-2005, Chen Gen participated in NIH project “parasitc zoonosis transmission in China", and undertaked hydatid disease prevalence and prevention research.

In 2008, he participated in Natural Science Fund project "Research on building wetland sewage treatment system in the Yellow River irrigation area and agricultural ecological restoration " ( No. 30770390 ), mainly on the biological soil nematode diversity research.

In 2008，he participated in Gansu Province Natural Science Fund Project “Research on Helicobacter pylori pathogenicity and genetic characteristics of urease effect in high nickel environment of Hexi Corridor " ( No . 0803RJZA073 ), mainly on experimental study of Helicobacter pylori.

In 2010, he presided over Free Exploration Project of The Central Universities Basic Scientific Research Expenses "research on intestinal lactobacillus affecting nematode Caenorhabditis elegans aging mechanism" ( No. lzujbky-2010-124 ), and undertaked Caenorhabditis elegans as a model organism for the study of the mechanisms of aging.

In 2010, he participated in Gansu Province Natural Science Fund project "Antihydatid effects and toxicity studies of albendazole sulfoxide and its enantiomers" ( No. 1010RJZA103 ), and undertaked hydatid animal experimental study.

In 2011, he presided over the National Natural Science Foundation project "Research on Caenorhabditis elegans as model for the study of parasite resistance ( No. 31172174 ), and was responsible for the design, execution and completion of this project.

In 2011, he participated in two National Natural Science Foundation "research of based on the visualization of complex bandwidth focal ultrasound induction and target control of drug treatment for hepatic hydatid cyst and its mechanism of action" ( No.81171632 ), and "research on environment process and ecology effect of combined pollution in the upper reaches of the Yellow River agriculture ecological system" ( No.41171391 ).

In 2011, he presided over the Spring plan of Ministry of Education "Transmission risk assessment research of leishmaniasis in Gansu province Longnan region" ( No.Z2010083 ), responsible for the design, execution and completion.

Chen Gen has published more than 20 papers, and took part in writing 1 teaching book.

四、发表论文

近三年已发表主要论文

1. Gen Chen, Jie Qin, Dazhong Shi, Yingmei Zhang, Weihong Ji. Diversity of Soil Nematodes in Areas Polluted with Heavy Metalsand Polycyclic Aromatic Hydrocarbons (PAHs) in Lanzhou,China. Environmental Management, 2009, 44: 163–172

2. 陈根, 刘海军, 刘婷, 包根书, 韩俭, 景涛, 周伟. “5·12”地震前后陇南市虫媒传染病流行病学分析. 中国媒介生物学及控制杂志, 2011, 22(4)：385-387.

CHEN Gen, LIU Hai-jun, LIU Ting, BAO Gen-shu, HAN Jian, JING Tao, ZHOU Wei, Epidemiological analysis of insect-borne diseases before and after May 12 Earthquake in Longnan, Gansu, China. Chinese Journal of Vector Biology and Control, 2011, 22(4)：385-387.

3. 陈根, 包根书, 韩俭, 景涛. 甘肃省玛曲县高原鼠兔肝毛细线虫感染的调查, 中国病原生物学杂志, 2011, 6(3): 215-216.

CHEN Gen; BAO Gen-shu; HAN Jian; JING Tao. Infection of Capillaria hepatica in Ochotona curzoniae in Maqu County,Gansu Province,China. Journal of Pathogen Biology(in Chinese), 2011, 6(3): 215-216.

4. 陈根, 南克祎, 赵宗国, 刘海军, 包根书, 韩俭, 姜雯雯, 景涛, 史大中. “5.12”地震对甘肃灾区人群常见卫生习惯、腹泻和儿童肠道蠕虫感染的影响[J]. 中国病原生物学杂志, 2010, (11): 附页4-5.

CHEN Gen; NAN Ke-wei; ZHAO Zong-guo; et al. Influence of a "5.12" earthquake on sanitary habits,diarrhea,and intestinal worm infection of children in rural populations of the Wudu area of Gansu Province. Journal of Pathogen Biology(in Chinese), 2010, (11): appendix page 4-5.

5. 田婷，冯楠, 胡晓梅, 李铁铮, 南伟, 陈根(通讯作者). Wistar 大鼠缺铁性贫血模型的建立. 当代医学, 2011, 17(35): 41-42

TIAN Ting, FENG Nan,  HU Xiao-Mei, LI Tie-Zhen, NAN Wei, CHEN Gen*. Wistar rat iron-deficiency anemia model. Contemporary Medicine(in Chinese), 2011, 17(35): 41-42

6. 梁晓萍, 张丽秀, 张多强, 张建芳, 张娟, 罗晓慧, 罗荣, 陈根, 韩俭. 河西走廊中段地区上消化道疾病患者幽门螺杆菌感染状况. 中国病原生物学杂志. 2011, 6(4): 257-259

LIANG Xiao-ping, ZHANG Li-xiu, ZHANG Duo-qiang, ZHANG Jian-fang, ZHANG Juan, LUO Xiao-hui, LUO Rong, CHEN Gen, HAN Jian. The prevalence of Helicobacter pylori infection among patients with an upper gastrointestinal tract disease in the middle of the Hexi Corridor. Journal of Pathogen Biology(in Chinese), 2011, 6(4): 257-259

7. 蒋次鹏, 陈根. 包虫病(棘球绦虫病)临床分类的探讨[J]. 国际医学寄生虫病杂志. 2010, 37(4): 212-216

JIANG Ci-peng, CHEN Gen. An approach to clinical taxonomy of liver echinococcosis. International Journal Of Medical Parasitic Diseases, 2010, 37(4): 212-216

8. 王竞秋, 尹少甫, 强尧生, 景涛, 陈根, 韩俭. 兰州地区人群血清幽门螺杆菌致病因子抗体与上消化道疾病的关系. 中国病原生物学杂志, 2010, (11): 815-817.

WANG Jing-qiu, YIN Shao-fu, QIANG Yao-sheng, JING Tao, 4; CHEN Gen, HAN Jian. 4 Study on the relationship between antibodies to Helicobacter pylori virulence factors and upper GI tract disease. Journal of Pathogen Biology(in Chinese),

9. 焦志刚, 李玉华, 张富花, 陈根, 景涛, 韩俭. 武威市农村居民HAV及HBV感染状况分析. 中国公共卫生, 2009, 25(5): 620-621.

JIAO Zhi-gang, LI Yu-hua, ZHANG Fu-hua, CHEN Gen, et al. Prevalence of HAV and HBV among rural people of Wuwei area,Gansu province. Chinese Journal of Public Health, 2009, 25(5): 620-621.

10. 王轶, 王琪, 陈根, 包根书, 史大中. 川芎嗪和阿苯达唑联合治疗小鼠继发性泡球蚴病的疗效观察.中国病原生物学杂志，2008，3(6)：443-446.

WANG Yi, WANG Qi, CHEN Gen, BAO Gen-shu, SHi Da-zhong. Effect of tetramethylpyrazine combined with albendazole on the secondary Alveolar echinococcosis in mice