阎文锦
【基本情况】
姓名，阎文锦，职称，教授，基础医学院药理学研究所，学术型博士研究生导师、学术型硕士研究生导师。
【学习经历】
1993.9—1997.07兰州大学化学系，学士
2002.9—2007.07兰州大学生命科学学院，博士
【工作经历】
2010.02—2012.05兰州大学基础医学院，讲师
2012.06—2018.10兰州大学基础医学院，副教授
2018.10—至今兰州大学基础医学院，教授
【目前承担课程】
《药理学》、《现代药理学理论基础》等。
【主要科研成果】
研究方向：含氟小分子药物的发现和人工智能辅助药物发现。
主持或参与科研项目：
1.国家自然科学基金面上项目“催化不对称[3+3]环加成合成含三氟甲基哌啶化合物的研究及在药物活性分子合成中的应用”（No.81872723，2019-2022
2.国家自然科学基金面上项目“3-烷氧羰基靛红亚胺的合成及其在合成手性双取代3-氨基氧化吲哚化合物方面的应用 ” ( No. 21272108 ), 2013-2016
3, 校企合作项目, 有关TB-002d多肽分子在治疗特发性肺纤维化临床前机制研究
发表主要论文或专著:10篇以内代表性成果即可，容易产生学术争议的论文尽量避免。
1.Qushuo Chen, Changyan Yang, YihaoXie, Yuqiang Wang, Xiaoxu Li, * Kairong Wang, * Jinqi Huang, * and Wenjin Yan* GM-Pep: A High Efficiency Strategy to De Novo Design Functional Peptide Sequences. J. Chem. Inf. Model.2022, 62, 2617−2629;
2.Yabo Deng, Yongzhen Li, Yalan Wang, Shuo Sun, Sichao Ma, PengfeiJia, Wenguang Li,* Kairong Wang,* Wenjin Yan* Efficient enantioselective synthesis of CF2H-containing dispiro[benzo[b]thiophene-oxindole-pyrrolidine]s via organocatalytic cycloaddition.Org. Chem. Front., 2022, 9, 210–215;
3, Yabo Deng, Shuo Sun, Yuqiang Wang, PengfengJia, Wenguang Li, * Kairong Wang, * Wenjin Yan*Asymmetric Synthesis of Chiral α-CF2H Spiro[Indoline-3,3′-Thiophene] via Phase-Transfer Catalyzed Sulfa-Michael/Michael Domino Reaction. Advanced Synthesis & Catalysis2022, 364, 811-830.
4, Yabo Deng, Zhenghao Dong, Fengyun Gao, YifeiGuo, Mengmeng Sun, Yongzhen Li, Yalan Wang, QushuoChen, Kairong Wang,* Wenjin Yan*The Regio-Controllable Enantioselective Synthesis of Chiral Trifluoromethyl -Containing Spiro-Pyrrolidine-Pyrazolone Compounds via Amino-Regulated 1,3-Proton Migration Reaction. J. Org. Chem.2021, 84, 13011-13024
5, Fengyun Gao, YifeiGuo, Mengmeng Sun, Yalan Wang, Changyan Yang, Yuqiang Wang, Kairong Wang* and Wenjin Yan*Title：Catalytic Asymmetric Construction of Tertiary Carbon Centers Featuring an α‑Difluoromethyl Group with CF2H‑CH2‑NH2 as the “Building Block”. Org. Lett.2021, 23, 2584−2589
6,Fengyun Gao, Boyu Li, Yalan Wang, Qushuo Chen, Yongzhen Li, Kairong Wang* and Wenjin Yan*Stereoselective synthetic strategies of stereogenic carbon centers featuring a difluoromethyl group.Org. Chem. Front., 2021, 8, 2799-2819
7,Jingjing Zhou, Lishi Zhang, Yuhang He, Kexin Liu, Fangfang Zhang, Hanru Zhang, Yaqi Lu, Changyan Yang, Zhaopeng Wang, Muhammad Subaan Fareed, XiaoleiLiang,Wenjin Yan*,Kairong Wang*An optimized analog of antimicrobial peptide Jelleine-1 shows enhanced antimicrobial activity against multidrug resistant P. aeruginosa and negligible toxicity in vitro and in vivo, Euro. J. Med. Chem.2021, 219, 113430;
8, FengjingJia,Jiayi Wang,Lishi Zhang,Jingjing Zhou,Yuhang He,Yaqi Lu,Kexin Liu,Wenjin Yan*,Kairong Wang*,Multiple action mechanism and in vivo antimicrobial efficacy of antimicrobial peptide Jelleine-I, J. Pep. Sci.2021, 27, e3294;
9, Jinxiu Peng, Shuai Qiu, Fengjing Jia, Lishi Zhang, Yuhang He, Fangfang Zhang, Mengmeng Sun, Yabo Deng, Yifei Guo,Zhaoqing Xu,Xiaolei Liang, Wenjin Yan*,Kairong Wang*, The introduction of l‑phenylalanine into antimicrobial peptide protonectin enhances the selective antibacterial activity of its derivative phe‑Prt against Gram‑positive bacteria, Amino Acids2021,53, 23–32
10, Boyu Li, Fengyun Gao, Xing Feng, Mengmeng Sun, YifeiGuo, Dongwa Wen, Yabo Deng, Jinqi Huang, Kairong Wang* and Wenjin Yan*, Highly efficient enantioselective synthesis of bispiro[benzofuran- oxindole-pyrrolidine]s through organocatalytic cycloaddition, Org. Chem. Front., 2019，6，1567.
【联系方式】