郭玎玎

职务/职称：副教授/硕导

研 究 所：天然药物化学生物学研究所

电子邮件：guodd@lzu.edu.cn

办 公 室：勤博楼4012室

【基本情况】

2011/02-至今，兰州大学，药学院，副教授，硕导

2016.12-2018.01, Seoul National University，活性天然产物研究，兼职副教授

2010/03-2011/02, Seoul National University，Research Institute for Agriculture and Life Sciences，博士后

2005/03-2010/02, Seoul National University，Pharmaceutics，博士

2001/09-2004/7，延边大学，遗传学，硕士

1997/09-2001/07，吉林农业大学，动物科学，学士

【研究方向】

活性天然产物筛选及分子作用机制；细菌多重耐药性产生机制。

【主讲课程】

中药资源的开发利用及真伪鉴别

生物化学与分子生物学

【研究成果】

[1] Ding-Ding Guo, Seong-Ho Hong, Hu-Lin Jiang, Ji-Hye Kim, Arash Minai-Tehrani, Ji-Eun Kim, Ji-Young Shin, Tao Jiang, You-Kyoung Kim, Yun-Jaie Choi, Chong-Su Cho and Myung-Haing Cho. Synergistic effects of Akt1 shRNA and paclitaxel-incorporated conjugated linoleic acid-coupled poloxamer thermosensitive hydrogel on breast cancer. Biomaterials, 2012, 33, 2272-2281.

[2] Ding-Ding Guo, Cheng-Xiong Xu, Ji-Shan Quan, Chung-Kil Song, Hua Jin, Dae-Duk Kim, Yun-Jaie Choi, Myung-Haing Cho and Chong-Su Cho. Synergistic anti-tumor activity of paclitaxel-incorporated conjugated linoleic acid-coupled poloxamer thermosensitive hydrogel in vitro and in vivo. Biomaterials, 2009, 30(27), 4777-4785.

[3] Ding-Ding Guo, Hyun-Seuk Moon, Rohidas Arote, Ji-Hye Seo, Ji-Shan Quan, Yun-Jaie Choi, Chong-Su Cho. Enhanced anticancer effect of conjugated linoleic acid by conjugation with Pluronic F127 on MCF-7 breast cancer cells. Cancer Letters, 2007, 254(2), 244-254.

[4] Hyun-Seuk Moon, Ding-Ding Guo, Hong-Gu Lee, Yun-Jaie Choi, Jae-Seong Kang, Kyungmin Jo, Jeong-Min Eom, Cheol-Heui Yun and Chong-Su Cho. Alpha-eleostearic acid suppresses proliferation of MCF-7 breast cancer cells via activation of PPARγ and inhibition of ERK 1/2. Cancer Science, 2010, 101(2), 396-402.

[5] Hyun-Seuk Moon, Ji-Hye Seo, Ding-Ding Guo, Hong-Gu Lee, Prati Bajracharya, Yun-Jaie Choi, Keun-Soo Jeon , Chong-Rae Park and Chong-Su Cho. Oxidative Stabilization of Conjugated Linoleic Acid by One-pot PEGylation. Macromolecular Research, 2011, 19(8), 822-826.

[6] Woo Kyun Bae, Ji Hee Lee, Sang Joon Lee, Myong Suk Park, Jun Eul Hwang, Hyun Jeong Shim, Sang Hee Cho, Ding-Ding Guo, Chong-Su Cho, In-Kyu Park and Ik Joo Chung. Enhanced Anti-Cancer Effect of 5-Fluorouracil Loaded into Thermo-Responsive Conjugated Linoleic Acid-Incorporated Poloxamer Hydrogel on Metastatic Colon Cancer Models. Journal of Nanoscience and Nanotechnology 11, 1425-1428, 2011.

[7] Kang Mi Lan, Hu-lin Jiang, Ding Ding Guo, Chong Soo Cho, Sang Gyun Kang, Deog Yong Lee, Nabin Rayamahji, Yeon Soo Seo, Han Sang Yoo. Chitosan Microspheres Containing Bordetella bronchiseptica Antigens as Novel Vaccine Against Atrophic Rhinitis in Pigs. Journal of Microbiology and Biotechnology 2008, 18(6): 1179-1185.

[8] Ji-Hye Seo, Hyun-Seuk Moon, In-Yong Kim, Ding-Ding Guo, Hong-Gu Lee, Yun-Jaie Choi, Chong-Su Cho. PEGylated conjugated linoleic acid stimulation of apoptosis via a p53-mediated signaling pathway in MCF-7 breast cancer cells. European Journal of Pharmaceutics and Biopharmaceutics, 2008, 70(2), 621-626.

[9] Hyun-Seuk Moon, Hong-Gu Lee, Ji-Hye Seo, Ding-Ding Guo, In-Yong Kim, Chung-Soo Chung, Tae-Gyu Kim, Yun-Jaie Choi, Chong-Su Cho. Lipolysis is stimulated by PEGylated conjugated linoleic acid through the cyclic adenosine monophosphate-independent signaling pathway in 3T3-L1 cells: Activation of MEK/ERK MAPK signaling pathway and hyper-secretion of adipo-cytokines. Journal of Cellular Physiology, 2008, 214 (2), 283-294.

[10] Ji-Shan Quan, Hu-Lin Jiang, Eun-Mi Kim, Hwan-Jeong Jeong, Yoon-Jaie Choi, Ding-Ding Guo, Mi-Kyong Yoo, Hong-Gu Lee and Chong-Su Cho. pH-sensitive and mucoadhesive thiolated Eudragit-coated chitosan microspheres. International Journal of Pharmaceutics. 2008, 359(1-2), 205-210.

[11] Hyun-Seuk Moon, Hong-Gu Lee, Ji-Hye Seo, Ding-Ding Guo, In-Yong Kim, Chung-Soo Chung, Tae-Gyu Kim, Yun-Jaie Choi, Chong-Su Cho. Lipolysis is stimulated by PEGylated conjugated linoleic acid through the cyclic adenosine monophosphate-independent signaling pathway in 3T3-L1 cells: Activation of MEK/ERK MAPK signaling pathway and hyper-secretion of adipo-cytokines. Journal of Cellular Physiology, 2008, 214 (2), 283-294.

[12] Hyun-Seuk Moon, Hong-Gu Lee, Ji-Hye Seo, Chung-Soo Chung, Ding-Ding Guo, Tae-Gyu Kim, Yun-Jaie Choi, Chong-Su Cho. Leptin-induced matrix metalloproteinase-2 secretion is suppressed by trans-10,cis-12 conjugated linoleic acid. Biochemical and Biophysical Research Communications. 2007, 356(4), 955-960.

[13] Hyun-Seuk Moon, Ding-Ding Guo, Ho-Hyun Song, In-Yong Kim, Hu-Lin Jiang, You-Kyoung Kim, Chung-Soo Chung, Yun-Jaie Choi, Hong-Ku Lee and Chong-Su Cho. Regulation of adipocyte differentiation by PEGylated all-trans retinoic acid: reduced cytotoxicity and attenuated lipid accumulation. Journal of Nutritional Biochemistry, 2007, 18(5), 322-331.

[14] Mi Lan Kang, Hu-Lin Jiang, Sang Gyun Kang, Ding-Ding Guo. Pluronic F127 enhances the effect as an adjuvant of chitosan microspheres in the intranasal delivery of Bordetella bronchiseptica antigens containing dermonecrotoxin. Vaccine, 2007, 25 (23), 4602-4610.

[15] Seog-Jin Seo, Hyun-Seuk Moon, Ding-Ding Guo, Sang-Heon Kim, Toshihiro Akaikec and Chong-Su Cho. Receptor-mediated delivery of all-trans-retinoid acid (ATRA) to hepatocytes from ATRA-loaded poly(N-p-vinylbenzyl-4-o-β-d-galactopyranosyl-d-gluconamide) nanoparticles. Materials Science and Engineering: C, 2006, 26(1), 136-141.

[16] Chong-Su Cho, Ding-Ding Guo, Hu-Lin Jiang, You-Kyoung Kim, Yun-Jaie Choi and Myung-Haing Cho. Design of degradable polyethylenimines as DNA and siRNA carriers in vitro and in vivo. Journal of the National Academy of Sciences Republic of Korea, 2010, 49(1), 293-322.

[17] Ding-Ding Guo, Rohidas Arote, Hu-Lin Jiang, Mi-Kyong Yoo, Hyun-Seuk Moon, Chong-Su Cho. Release of All-Trans Retinoic Acid (RA) from RA-loaded Poly(ester amine) Based on Polyethylenimine and Polycaprolactone for Intracellular Delivery. Key Engineering Materials. 2007, 342-343, 429-432.

[18] Ji-Hye Seo, Hyun-Seuk Moon, Ding-Ding Guo, Hong-Goo Lee, Yun-Jaie Choi, Chong-Su Cho. PEGylation of Conjugated Linoleic Acid and Its Application as an Anti-Cancer Prodrug. Key Engineering Materials. 2007, 342-343, 441-444.

【研究项目】

[1] 国家自然科学基金/面上项目（21772073）：苯磺酰腙参与的化学反应研究及其在药物设计与合成中的应用，参与。2018.01-2021. 12。

[2] 国家自然科学基金地区科学基金项目(81560715)：矿物药雄黄增效减毒新技术的相关基础理论研究，参与。2016.01-2019.12。

[3] 科技部国家国际科技合作专项项目(2012DFA30480)：第二代促血小板生成素的合作研究，参与。2013-2015。