李加忠

职务/职称：副教授/硕导

研 究 所：药物化学研究所

电子邮件：lijiazhong@lzu.edu.cn

【基本情况】

兰州大学药学院副院长，博士，副教授,硕士生导师。2002年6月毕业于兰州大学化学化工学院国家基础科学研究与教学人才培养基地班，获得理学学士学位。2004年9月开始，在兰州大学化学化工学院分析化学专业硕博连读，并于2009年获得博士学位。2008年10月至2010年4月获得中国国家留学基金委员会的项目资助，赴意大利Insubria大学进行联合培养。

【研究方向】

药物设计与发现、中药方及中药现代化研究等

【主讲课程】

本科生《药物设计学》、《医学统计学》，研究生《计算机辅助药物设计》

【获奖情况】

2013年首届“甘肃省优秀药学工作者”

2015年首届“兰州大学青年五四奖章”

【研究成果】

[1] Lingyan Wang, Jiazhong Li*, Structure-activity relationship analysis of carbobiocyclo and oxabicyclo succinimide analogs as potential androgen receptor antagonists, Journal of Biomolecular Structure and Dynamics, 2017, 35, 1371643.

[2] Hongli Liu, Lingyan Wang, Jiaqi Tian, Jiazhong Li*, Huanxiang Liu, Molecular Dynamics Studies on the Enzalutamide Resistance Mechanisms Induced by Androgen Receptor, Journal of Cellular Biochemistry, 2017, 118, 2792-2801.

[3] Yuwei Wang, Rui Han, Huimin Zhang, Hongli Liu, Jiazhong Li*, Huanxiang Liu, Paola Gramatica, Combined Ligand/Structure-Based Virtual Screening and Molecular Dynamics Simulations of Steroidal Androgen Receptor Antagonists, Biomed Research International, 2017, Vol 2017, Article ID 3572394, 18 pages.

[4] Hongli Liu, Rui Han, Jiazhong Li*, Huanxiang Liu, Lifang Zheng, Molecular mechanism of R-bicalutamide switching from androgen receptor antagonist to agonist induced by amino acid mutations using molecular dynamics simulations and free energy calculation, Journal of Computer-Aided Molecular Design, 2016, 30, 1189–1200.

[5] Hongli Liu, Xiaoli An, Shuyan Li, Yuwei Wang, Jiazhong Li*, Huanxiang Liu, Interaction mechanism exploration of R-bicalutamide/S-1 with WT/W741L AR using molecular dynamics simulations, Molecular BioSystems, 2015, 11, 3347-3354.

[6] Jiazhong Li*, Fang Bai, Huanxiang Liu, Paola Gramatica. Ligand Efficiency Outperforms pIC50 on Both 2D MLR and 3D CoMFA Models: A Case Study on AR Antagonists. Chemical Biology & Drug Design, 2015, 86, 1501-1517.

[7] Yuwei Wang, Fang Bai, Hong Cao, Jiazhong Li*, Huanxiang Liu, Paola Gramatica. A Combined Quantitative Structure-Activity Relationship Research of Quinolinone Derivatives as Androgen Receptor Antagonists. Combinatorial Chemistry & High Throughput Screening, 2015, 18, 834-845.

[8] Jiazhong Li*, Xin Wang, Huanxiang Liu, Hongyu Li. In silico classification and prediction of VIP derivatives as VPAC1/VPAC2 receptor agonists/antagonists. Combinatorial chemistry & high throughput screening, 2015, 18, 33-41.

[9] Jiazhong Li*, Shuyan Li, Chongliang Bai, Huanxiang Liu, Paola Gramatica. Structural requirements of 3-carboxyl-4(1H)-quinolones as potential antimalarials from 2D and 3D QSAR analysis Journal of Molecular Graphics and Modelling, 2013, 44, 266–277.

[10] Jiazhong Li*, Huanxiang Liu, Xing Huo, Paola Gramatica. Structure-Activity Relationship Analysis of the Thermal Stabilities of Nitroaromatic Compounds Following Different Decomposition Mechanisms. Molecular Informatics, 2013, 32, 193-202.

[11] Xing Huo, Jiazhong Li*. Quantitative structure–activity relationship analysis of a novel series of chemicals antagonizing WT and MT AR. Chemometrics and Intelligent Laboratory Systems, 2011, 107 283-289.

[12] Jiazhong Li, Shuyan Li, Beilei Lei, Huanxiang Liu, Xiaojun Yao, Mancang Liu, Paola Gramatica, A new strategy to improve the predictive ability of the local lazy regression and its application to the QSAR study of melanin-concentrating hormone receptor 1 antagonists, Journal of Computational Chemistry, 2010, 31, 973-985.

[13] Jiazhong Li, Paola Gramatica, Classification and Identification of Androgen Receptor Antagonists with Various Methods and Consensus Approach, Journal of Chemical Information and Modeling, 2010, 50, 861-874.

[14] Jiazhong Li, Paola Gramatica, The importance of molecular structures, endpoints’ values, and predictivity parameters in QSAR research: QSAR analysis of a series of estrogen receptor binders, Molecular Diversity, 2010, 14, 687-696.

[15] Jiazhong Li, Paola Gramatica, QSAR classification of estrogen receptor binders and identification of pleiotropic EDCs, SAR & QSAR in Environmental Research, 2010, 21, 657-669.

【研究项目】

1. 国家自然科学基金青年基金(21205055)：抗CRPC前列腺癌的AR受体纯拮抗剂的设计、筛选与活性评价，负责人。

2. 甘肃省自然科学基金青年基金（2011GS04091）：甾体类雄激素受体拮抗剂作为前列腺癌治疗药物的研究，负责人。

3. 留学回国人员科技活动项目（第46批）：选择性雄激素受体调节剂（SARMs）的构效关系及作用机理研究，负责人。

4. 横向课题：枸杞鲜果真空冻干加工实验及成分分析研究，负责人。

5. 横向课题：枸杞精油、枸杞多糖有效成分分析及动物毒理实验研究，负责人。