郑丽芳

职务/职称：副教授/硕导

研 究 所：药物化学研究所

电子邮件：zhenglf@lzu.edu.cn

办 公 室：勤博楼2023室

【基本情况】
   　2002年毕业于兰州大学化学化工学院，2007年获兰州大学有机化学博士学位，2014年～2015年在英国谢菲尔德大学化学系做访问学者。

【研究方向】
   　抗肿瘤靶标药物合成和活性研究

【主讲课程】
   　《分析化学》

【研究成果】

[1] Zhang L, He D, Li K, Wang B, Zheng L*, Li J, Emodin targets mitochondrial cyclophilin D to induce apoptosis in HepG2 cells. Biomedicine & Pharmacotherapy. 2017, 90: 222–228 

[2] Li J, He D, Wang B, Zhang L, Li K, Xie Q, Zheng L*, Synthesis of hydroxycinnamic acid derivatives as mitochondria-targeted antioxidants and cytotoxic agents. Acta Pharmaceutica Sinica B, 2017,7: 106-115. 

[3] Bao YF, Li JY, Zheng LF *, Li HY.; Antioxidant activities of cold-nature Tibetan herbs aresignifcantly greater than hot-nature ones and are associatedwith their levels of total phenolic components. Chinese Journal of Natural Medicines, 2015, 13: 609-617. 

[4] Yin F, Wu Z, Zheng L*, Stability, cytotoxicity, and saturation effect of the free radical-scavengingcinnamic acid - dopaminehybrid antioxidants. Journal of Chinese Pharmaceutical Sciences, 2015, 24: 148–155. 

[5] Wu Z, Zheng L, Li Y, et al, Synthesis and structure–activity relationships of phenylpropanoid amides of octopamine and dopamine on tyrosinase inhibition and antioxidation. Food chemistry. 2012, 134: 1128-1131 

[6] Zheng LF, Dai F, Zhou B, et al, Prooxidant activity of hydroxycinnamic acids on DNA damage in the presence of Cu (II) ions:  Mechanism and structure-activity relationship. Food and Chemical Toxicology. 2008, 46: 149-156 

[7] Zheng L, Wei Q, Zhou B, et al, Synthesis of 1,1,2-triphenylethylenes and their antiproliferative effect on human cancer cell lines. Anti-cancer drugs. 2007, 18: 1039-1044 

[8] Zheng LF, Wei QY, Cai YJ, et al, DNA damage induced by resveratrol and its synthetic analogues in the presence of Cu (II) ions: Mechanism and structure-activity relationship. Free Radical Biology and Medicine. 2006, 41: 1807-1816  

【研究项目】

1. 国家自然科学基金青年项目（21302079）：以线粒体为作用靶点的羟基肉桂酸类生物抗氧化剂的设计、合成和生物活性研究，负责人。 

2. 甘肃省自然科学基金青年项目（1208RJYA014）：青海产藏药阴阳属性与抗氧化活性相关性的实验研究，负责人